A systematic review and meta-analysis led by GMR researchers has indicated a high prevalence of polypharmacy (concurrent use of multiple medications) among current and ex serving populations.

The meta-analysis, published in the Journal of Affective Disorders, reported general polypharmacy among 49% of current and ex serving military populations, and psychotropic polypharmacy (use of two or more medicines that affect cognitive function) among 36% of current and ex-serving military cohorts in the identified studies.

Polypharmacy increases the risk of drug interactions and associated adverse effects. This paper is the first step of a two-year, RSL-funded project to investigate the prevalence and impact of polypharmacy among ex serving ADF populations in Australia, and to recommend suitable interventions to support veteran wellbeing.

“This review and collation of 19 existing global studies identified a high prevalence of polypharmacy among current and ex serving populations, in addition to factors like diagnosis of PTSD that are associated with increased risk,” GMR Research Fellow, Dr Sanket Raut said.

The next phases of the study will focus on collecting data from Australian veterans to acquire local data, and from clinicians to gain insight into current prescribing patterns.

The findings of the review emphasise the importance of targeted education and prevention strategies to reduce polypharmacy, and research efforts into non-pharmacological interventions to alleviate the burden of polypharmacy and enhance the wellbeing of veterans.

“Ultimately, we are aiming to support both clinicians and veterans by developing relevant clinical guidelines, in addition to creating online learning modules for veterans on RSL’s online Be:Well program, to empower them with a deeper understanding of safe use of medications,” Dr Raut said.

RSL Be:Well is an online program designed specifically for veterans, offering a range of resources to support veterans’ physical, mental and emotional health.

Research paper: Prevalence and factors associated with polypharmacy in military and veteran publications: A systematic review and meta-analysis.