Liver research publications 2020 – 2025

2025

Stimulation of macrophages: a therapeutic approach to improve liver regeneration during ischemia-reperfusion injury in rats

Schulze, S., Keshvari, S., Bridle, K. R., Hume, D. A. and Irvine, K. M.  In Press, World Journal of Gastroenterology 2025.

 

 

2024

Mesenchymal stem cell-derived liver-on-a-chip reconstitutes human liver structure and function

Brooks, A., Yang, H., SIm Barkauskas, D., Ranaweera, S., Zou, D., Goh, S., Ruan, Q., Bridle, K. R., Crawford, D. H., Liu, X., Roberts, M. S., Doran, M., Liang, X., Zhao, C. X. and Wang, H.  PNAS (submitted) 2024.  

 

 

Cancer Metastasis-on-a-Chip for Modeling Metastatic Cascade and Drug Screening

Brooks, A., Zhang, Y., Chen, J. and Zhao, C. X. Adv Healthc Mater 2024. e2302436. 10.1002/adhm.202302436: https://www.ncbi.nlm.nih.gov/pubmed/38224141  

 

Nanoagonist Boosts Antitumor Immunity of Therapeutic DNA Vaccines

Jia, W., Chandra, J., Teoh, S. M., Tolley, L., Yang, H., Tse, B. W. C., Sokolowski, K. A., Liang, X., Crawford, D. H. G., Steel, J. C., Yu, C., Roberts, M. S., Frazer, I. H., Chen, Y., Wang, H. and Yu, M. STING Nano Lett 2024. 24(49): 15588-97. 10.1021/acs.nanolett.4c03846: https://www.ncbi.nlm.nih.gov/pubmed/39621441

 

A-specific PI3K inhibitor improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer

Ruan, Q., Chen, T., Yang, H., Bridle, K. R., He, Y., Burke, L. J., Wickramasuriya, L., Cao, L., Yan, W., Hooper, J. D., Liu, Y., Wang, H., Crawford, D. H. and Liang, X.  Submitted, Journal of Hepatology 2024.

 

Identification and characterization of TM4SF1(+) tumor self-seeded cells

Yang, H., Wang, H., He, Y., Yang, Y., Thompson, E. W., Xia, D., Burke, L. J., Cao, L., Hooper, J. D., Roberts, M. S., Crawford, D. H. G. and Liang, X.  Cell Rep 2024. 43(7): 114512. 10.1016/j.celrep.2024.114512: https://www.ncbi.nlm.nih.gov/pubmed/39003738

 

 

 

2023

The impact of posttraumatic stress disorder on upper gastrointestinal investigations in Australian Defence Force veterans: a retrospective review.

Crawford, D. H. G., Mellor, R., Duenow, P. and Connelly, L. B.  Intern Med J 2023. 53(5): 841-4. 10.1111/imj.16088: https://www.ncbi.nlm.nih.gov/pubmed/37145886

 

Post-traumatic stress disorder is associated with a higher rate of polypectomy independent of an increased frequency of colonoscopy in Australian veterans: a retrospective review.

Crawford, D. H. G., Mellor, R., Teo, A., Duenow, P. and Connelly, L. B. Intern Med J 2023. 53(8): 1423-8. 10.1111/imj.15818: https://www.ncbi.nlm.nih.gov/pubmed/35559586

 

 

Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver

Crawford, D. H. G., Ramm, G. A., Bridle, K. R., Nicoll, A. J., Delatycki, M. B. and Olynyk, J. K. Hepatol Int 2023. 17(3): 522-41. 10.1007/s12072-023-10510-3: https://www.ncbi.nlm.nih.gov/pubmed/37067673

 

A salivary biomarker panel to detect liver cirrhosis

Trevisan Franca de Lima, L., Crawford, D. H. G., Broszczak, D. A., Zhang, X., Bridle, R. K. and Punyadeera, C.  iScience 2023. 26(7): 107015. 10.1016/j.isci.2023.107015: https://www.ncbi.nlm.nih.gov/pubmed/37360686

Three-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification

Zhang, J. Z., Yang, C. X., Gao, S., Bu, J. F., Li, Q. Q., Wang, H. L., Yang, K. N., Tong, S. S., Qian, L. J., Zhang, J., Hua, R., Sun, Y. W., Yan, J. Y. and Chen, W.  World J Surg Oncol 2023. 21(1): 239. 10.1186/s12957-023-03126-2: https://www.ncbi.nlm.nih.gov/pubmed/37542314

Nanoparticle elasticity regulates the formation of cell membrane-coated nanoparticles and their nano-bio interactions

Zou, D., Wu, Z., Yi, X., Hui, Y., Yang, G., Liu, Y., Tengjisi, Wang, H., Brooks, A., Wang, H., Liu, X., Xu, Z. P., Roberts, M. S., Gao, H. and Zhao, C. X.  Proc Natl Acad Sci U S A 2023. 120(1): e2214757120. 10.1073/pnas.2214757120: https://www.ncbi.nlm.nih.gov/pubmed/36574680

 

Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers

Balaji, A., Bell, C. A., Houston, Z. H., Bridle, K. R., Genz, B., Fletcher, N. L., Ramm, G. A. and Thurecht, K. J.  Biomaterials 2023. 302(122318. 10.1016/j.biomaterials.2023.122318: https://www.ncbi.nlm.nih.gov/pubmed/37708659  

 

 

2022

Long-term survival and postoperative complications of pre-liver transplantation transarterial chemoembolisation in hepatocellular carcinoma: A systematic review and meta-analysis

Butcher, D. A., Brandis, K. J., Wang, H., Spannenburg, L., Bridle, K. R., Crawford, D. H. and Liang, X.  Eur J Surg Oncol 2022. 48(3): 621-31. 10.1016/j.ejso.2021.09.017: https://www.ncbi.nlm.nih.gov/pubmed/34774394

 

Potential Therapeutic Targets in Gallbladder Cancer

Cao, L., Bridle, K. R., Shrestha, R., Prithviraj, P., Crawford, D. H. G. and Jayachandran, A. CD73 and PD-L1 as  Int J Mol Sci 2022. 23(3): 10.3390/ijms23031565: https://www.ncbi.nlm.nih.gov/pubmed/35163489

 

Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: A systematic review and meta-analysis

Wang, H., Liu, X., Bridle, K., Crawford, D. and Liang, X. Efficacy and safety of immune-modulating therapy for primary sclerosing cholangitis: A systematic review and meta-analysis. Pharmacol Ther 2022. 237(108163. 10.1016/j.pharmthera.2022.108163: https://www.ncbi.nlm.nih.gov/pubmed/35271884

 

 

 

2021

Prognostic Role of Immune Checkpoint Regulators in Cholangiocarcinoma: A Pilot Study

Cao, L., Prithviraj, P., Shrestha, R., Sharma, R., Anaka, M., Bridle, K. R., Kannourakis, G., Crawford, D. H. G. and Jayachandran, A.  J Clin Med 2021. 10(10): 10.3390/jcm10102191: https://www.ncbi.nlm.nih.gov/pubmed/34069452

 

Iron depletion attenuates steatosis in a mouse model of non-alcoholic fatty liver disease: Role of iron-dependent pathways

Crawford, D. H. G., Ross, D. G. F., Jaskowski, L. A., Burke, L. J., Britton, L. J., Musgrave, N., Briskey, D., Rishi, G., Bridle, K. R. and Subramaniam, V. N.  Biochim Biophys Acta Mol Basis Dis 2021. 1867(7): 166142. 10.1016/j.bbadis.2021.166142: https://www.ncbi.nlm.nih.gov/pubmed/33839281

 

Effect of metabolic syndrome components on the risk of malignancy in patients with gallbladder lesions

Deng, Z., Xuan, Y., Li, X., Crawford, W. J., Yuan, Z., Chen, Z., Brooks, A., Song, Y., Wang, H., Liang, X. and Chen, T.  J Cancer 2021. 12(5): 1531-7. 10.7150/jca.54617: https://www.ncbi.nlm.nih.gov/pubmed/33531998

 

Assessment and Transplantation of Orphan Donor Livers: A Back-to-Base Approach to Normothermic Machine Perfusion

Reiling, J., Butler, N., Simpson, A. H., Hodgkinson, P., Campbell, C., Lockwood, D., Bridle, K. J., Santrampurwala, N., Britton, L. J., Crawford, D. H., Dejong, C. H. C. and Fawcett, J. Reply. Liver Transpl 2021. 27(4): 602-3. 10.1002/lt.25894: https://www.ncbi.nlm.nih.gov/pubmed/33880856

 

Dual Targeting of Sorafenib-Resistant HCC-Derived Cancer Stem Cells

Shrestha, R., Bridle, K. R., Cao, L., Crawford, D. H. G. and Jayachandran, A.  Curr Oncol 2021. 28(3): 2150-72. 10.3390/curroncol28030200: https://www.ncbi.nlm.nih.gov/pubmed/34208001

 

TNF‑alpha‑mediated epithelial‑to‑mesenchymal transition regulates expression of immune checkpoint molecules in hepatocellular carcinoma

Shrestha, R., Bridle, K. R., Crawford, D. H. G. and Jayachandran, A.  Mol Med Rep 2020. 21(4): 1849-60. 10.3892/mmr.2020.10991: https://www.ncbi.nlm.nih.gov/pubmed/32319631

 

Immune checkpoint molecules are regulated by transforming growth factor (TGF)-beta1-induced epithelial-to-mesenchymal transition in hepatocellular carcinoma

Shrestha, R., Bridle, K. R., Crawford, D. H. G. and Jayachandran, A.  Int J Med Sci 2021. 18(12): 2466-79. 10.7150/ijms.54239: https://www.ncbi.nlm.nih.gov/pubmed/34104078

 

Combined Inhibition of TGF-beta1-Induced EMT and PD-L1 Silencing Re-Sensitizes Hepatocellular Carcinoma to Sorafenib Treatment

Shrestha, R., Prithviraj, P., Bridle, K. R., Crawford, D. H. G. and Jayachandran, A.  J Clin Med 2021. 10(9): 10.3390/jcm10091889: https://www.ncbi.nlm.nih.gov/pubmed/33925488

 

Self-reported Liver Disorders in Australian Vietnam War Veterans

Wang, H., Liang, X., Bridle, K. R. and Crawford, D. H.  J Military and Veterans’ Health 2021. 29(43-51.

C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation

Zhang, Y., Wang, H., Chen, T., Wang, H., Liang, X., Zhang, Y., Duan, J., Qian, S., Qiao, K., Zhang, L., Liu, Y. and Wang, J.  Hepatology 2021. 73(2): 692-712. 10.1002/hep.31304: https://www.ncbi.nlm.nih.gov/pubmed/32374916

 

Artificial cells for the treatment of liver diseases. Acta Biomater 2021

Zou, D., Wang, H., Liu, X., Xu, Z. P., Roberts, M. S. and Zhao, C. X.  130(98-114. 10.1016/j.actbio.2021.06.012: https://www.ncbi.nlm.nih.gov/pubmed/34126265

 

Inhibition of MLKL Attenuates Necroptotic Cell Death in a Murine Cell Model of Ischaemia Injury

Baidya, R., Gautheron, J., Crawford, D. H. G., Wang, H. and Bridle, K. R.  J Clin Med 2021. 10(2): 10.3390/jcm10020212: https://www.ncbi.nlm.nih.gov/pubmed/33435617   

 

Liver organoid as a 3D in vitro model for drug validation and toxicity assessment

Brooks, A., Liang, X., Zhang, Y., Zhao, C. X., Roberts, M. S., Wang, H., Zhang, L. and Crawford, D. H. G.  Pharmacol Res 2021. 169(105608. 10.1016/j.phrs.2021.105608: https://www.ncbi.nlm.nih.gov/pubmed/33852961  

 

A monochromophoric approach to succinct ratiometric fluorescent probes without probe-product crosstalk

Xin, K., Li, X., Guo, Y., Zhong, Y., Wang, J., Yang, H., Zhao, J., Guo, C., Huang, Y., Lei, Z., Ying, Y., Luo, X., Wang, H., Qian, X., Yang, W., Liang, X. and Yang, Y.  CCS Chemistry 2021. 3(8): 2307-15.

Australian recommendations for the management of hepatocellular carcinoma: a consensus statement.

Lubel, J. S., Roberts, S. K., Strasser, S. I., Thompson, A. J., Philip, J., Goodwin, M., Clarke, S., Crawford, D. H., Levy, M. T. and Shackel, N.  Med J Aust 2021. 214(10): 475-83. 10.5694/mja2.50885: https://www.ncbi.nlm.nih.gov/pubmed/33314233

 

 

2020

Association between Hereditary Hemochromatosis and HCC: a comprehensive review

Jayachandran, A., Shrestha, R., Bridle, K. R. and Crawford, D. H. Hepatoma Research 2020. 6(8. http://dx.doi.org/10.20517/2394-5079.2019.35

 

New mathematical modelling tools for co-culture experiments: when do we need to explicitly account for signalling molecules?

Jin, W., Wang, H., Liang, X., Roberts, M. S. and Simpson, M. J.  bioRxiv 2020. https://doi.org/10.1101/2020.01.13.905414

 

A Back-to-Base Approach to Normothermic Machine Perfusion

Reiling, J., Butler, N., Simpson, A., Hodgkinson, P., Campbell, C., Lockwood, D., Bridle, K., Santrampurwala, N., Britton, L., Crawford, D., Dejong, C. H. C. and Fawcett, J. Assessment and Transplantation of Orphan Donor Livers:  Liver Transpl 2020. 26(12): 1618-28. 10.1002/lt.25850: https://www.ncbi.nlm.nih.gov/pubmed/32682340

 

Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma.

Ruan, Q., Wang, H., Burke, L. J., Bridle, K. R., Li, X., Zhao, C. X., Crawford, D. H. G., Roberts, M. S. and Liang, X. Int J Cancer 2020. 147(6): 1519-27. 10.1002/ijc.32899: https://www.ncbi.nlm.nih.gov/pubmed/32010970

 

Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials.

Spannenburg, L., Sanchez Gonzalez, M., Brooks, A., Wei, S., Li, X., Liang, X., Gao, W. and Wang, H.  Eur J Surg Oncol 2020. 46(8): 1404-14. 10.1016/j.ejso.2020.04.052: https://www.ncbi.nlm.nih.gov/pubmed/32418754

 

The use of minimally invasive biomarkers for the diagnosis and prognosis of hepatocellular carcinoma.

Trevisan Franca de Lima, L., Broszczak, D., Zhang, X., Bridle, K., Crawford, D. and Punyadeera, C. Biochim Biophys Acta Rev Cancer 2020. 1874(2): 188451. 10.1016/j.bbcan.2020.188451: https://www.ncbi.nlm.nih.gov/pubmed/33065194

 

Imaging-based vascular-related biomarkers for early detection of acetaminophen-induced liver injury

Wang, H., Burke, L. J., Patel, J., Tse, B. W., Bridle, K. R., Cogger, V. C., Li, X., Liu, X., Yang, H., Crawford, D. H. G., Roberts, M. S., Gao, W. and Liang, X.  Theranostics 2020. 10(15): 6715-27. 10.7150/thno.44900: https://www.ncbi.nlm.nih.gov/pubmed/32550899

 

Hepatic artery classification based on three-dimensional CT

Yan, J., Feng, H., Wang, H., Yuan, F., Yang, C., Liang, X., Chen, W. and Wang, J.  Br J Surg 2020. 107(7): 906-16. 10.1002/bjs.11458: https://www.ncbi.nlm.nih.gov/pubmed/32057096

 

Sequential PDT and PTT Using Dual-Modal Single-Walled Carbon Nanohorns Synergistically Promote Systemic Immune Responses against Tumor Metastasis and Relapse

Yang, J., Hou, M., Sun, W., Wu, Q., Xu, J., Xiong, L., Chai, Y., Liu, Y., Yu, M., Wang, H., Xu, Z. P., Liang, X. and Zhang, C.  Adv Sci (Weinh) 2020. 7(16): 2001088. 10.1002/advs.202001088: https://www.ncbi.nlm.nih.gov/pubmed/32832363

 

Necroptosis in Hepatosteatotic Ischaemia-Reperfusion Injury

Baidya, R., Crawford, D. H. G., Gautheron, J., Wang, H. and Bridle, K. R. Int J Mol Sci 2020. 21(16): 10.3390/ijms21165931: https://www.ncbi.nlm.nih.gov/pubmed/32824744

 

Identification of hub genes and construction of transcriptional regulatory network for the progression of colon adenocarcinoma hub genes and TF regulatory network of colon adenocarcinoma

Wei, S., Chen, J., Huang, Y., Sun, Q., Wang, H., Liang, X., Hu, Z. and Li, X.  J Cell Physiol 2020. 235(3): 2037-48. 10.1002/jcp.29067: https://www.ncbi.nlm.nih.gov/pubmed/31612481

 

Computer-aided diagnosis of gallbladder polyps based on high resolution ultrasonography

Chen, T., Tu, S., Wang, H., Liu, X., Li, F., Jin, W., Liang, X., Zhang, X. and Wang, J.  Comput Methods Programs Biomed 2020. 185(105118. 10.1016/j.cmpb.2019.105118: https://www.ncbi.nlm.nih.gov/pubmed/31671340