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Recent Publications

1. L.M. Fletcher, M.L. Heritage, K.R. Bridle, G.J. Anderson, T.L. Murphy, D.H.G. Crawford (2008). Chronic alcohol consumption further suppresses hepcidin gene expression in Hfe -/- mice. Alcoholism Clinical and Experimental Research (submitted).

2. Y. Kobayashi, K.R. Bridle, G.A. Ramm, R.S. Britton, R. O'Neill and B.R. Bacon (2007). Effect of phorbol esters and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells. Liver International, 27(8):1066-1075 .

3. Urahashi T, Lynch SV, Kim YH, Balderson GA, Fawcett JW, Crawford DH, Strong RW. Undetected hepatocellular carcinoma in patients undergoing liver transplantation: is associated with favorable outcome. Hepatogastroenterology. 2007 Jun; 54 ( 76 ): 1192-5

4. Cebon J, Findlay M, Hargreaves C, Stockler M, Thompson P, Boyer M, Roberts S, Poon A, Scott AM, Kalff V, Garas G, Dowling A, Crawford D, Ring J, Basser R, Strickland A, Macdonald G, Green M, Nowak A, Dickman B, Dhillon H, Gebski V; Australasian Gastro-Intestinal Trials Group (AGITG) Ag0001H Investigators. Somatostatin receptor expression, tumour response, and quality of life in patients with advanced hepatocellular carcinoma treated with long-acting octreotide. Br J Cancer. 2006 Oct 9;95(7):853-61 .

5. K.R. Bridle, L. Li, R. O'Neill, R.S. Britton and B.R. Bacon (2006). Crosstalk between intracellular signaling pathways induced by IGF-1 and PDGF in rat hepatic stellate cells. Journal of Laboratory and Clinical Medicine, 147(5):234-241.

6. Gane EJ, Angus PW, Strasser S, Crawford DH, Ring J, Jeffrey GP, McCaughan GW; Australasian Liver Transplant Study Group. Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation. Gastroenterology . 2007 Mar;132(3):931-7

7. Gane EJ, Angus PW, Strasser S, Crawford DH, Ring J, Jeffrey GP, McCaughan GW; Australasian Liver Transplant Study Group. Lamivudine plus low-dose hepatitis B immunoglobulin to prevent recurrent hepatitis B following liver transplantation. Gastroenterology . 2007 Mar;132(3):931-7

8. Bridle KR, Cheung TK, Murphy TL, Walters M, Crawford DHG, Fletcher LM. Hepcidin Expression is Down-regulated in Alcohol-fed Rats: A Possible Pathogenic Factor in Alcohol-related Hepatic Siderosis. Alcoholism: Clinical and Experimental Research 2006;290(2):G343-51.

9. Hung D, Siebert G, Chang P, Whitehouse M, Fletcher L, Crawford D and Roberts M. Hepatic pharmacokinetics of propanol in rats with adjuvant-induced systemic inflammation. American Journal of Physiology: Gastrointestinal and Liver Physiology 2006;30(1):106-112 .

10. Powell LW, Dixon JL, Ramm GA, Purdie DM, Lincoln DJ, Anderson GA, Subramaniam VN, Hewett DG, Searle JW, Fletcher LM, Crawford DH, Rodgers H, Allen KJ, Cavanaugh JA, Bassett ML. Screening for hemochromatosis in asymptomatic subjects with or without a family history. Arch Intern Med. 2006;166(3):294-301

11. Subramaniam VN, Wallace DF, Dixon JL, Fletcher LM, Crawford DH. Ferroportin disease due to the A77D mutation in Australia . Gut 2005;54(7):1048-1049.

12. Crawford DHG, Fletcher LM, Hubscher SG, Stuart KA, Gane E, Angus PW, Jeffrey GP, McCaughan GW, Kerlin P, Powell LW, Elias EE. Liver Transplantation and hereditary hemochromatosis: Patient and graft survival and implications for pathogenesis. Hepatology 2004; 39(6) 1495-1498.

Editorial : Kowdley KV. Liver transplantation: An “in vivo” model for the pathophysiology of hemochromatosis . Hepatology 2004;39(6) 1495-1498

Correspondence : Bralet M, et al. No hepatic iron overload 12 yrs after liver transplantation for hereditary hemochromatosis. Hepatology 2004; 40(3): 762

Reply : Crawford D and Fletcher L . Hepatology 2004;39(6): 1495-1498

13. Stuart KA, Anderson GA , Frazer DM, Murphy TL, Powell LW, Fletcher LM, Crawford DH. Increased duodenal expression of DMT1 and Ireg1 in cirrhosis. Hepatology 2004;39(2):49-9.

14. Zekry A, Whiting P, Crawford DH, Angus PW, Jeffrey GP, Padbury RT, Gane EJ, McCaughan GW; Australian and New Zealand Liver Transplant Clinical Study Group. Liver transplantation for HCV-associated liver cirrhosis: predictors of outcomes in a population with significant genotype 3 and 4 distribution. Liver Transpl. 2003 Apr;9(4):339-47

15. Lockwood DS, Yeadon TM, Cloustan AD, Crawford DH, Fawcett J, Callaghan SA, Gotley DC . Tumor progression in hepatocellular carcinoma: relationship with tumor stroma and parenchymal disease. J Gastroenterol Hepatol . 2003;18(6):666-72

16. Bridle KR, Crawford DHG , and Ramm GA. Identification and characterization of the Hepatic Stellate Cell Transferrin Receptor. Am J Pathol 2003; 162(5):1661-1667.

17. Stuart KA, Anderson GJ, Frazer DM, Powell LW, McCullen M, Fletcher LM, Crawford DHG. Duodenal Expression of Iron Transport Molecules in Untreated Haemochromatosis Subjects. Gut 2003; 52(7) 953-999

18. Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, Subramaniam VN, Powell LW, Anderson GJ, Ram GA . Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003 Feb 22;361(9358):669-73

19. Bridle KR, Crawford DHG , Fletcher LM, Smith JL, Powell LW and Ramm GA.
Evidence for a sub-morphological inflammatory process in the liver
in haemochromatosis. J. Hepatol. 2003 38(4):425-432.

20. Sugo H, Balderson GA, Crawford DH, Fawcett J, Lynch SV, Strong RW, Futagawa S: Infulence of viral genotypes and rejection episodes on the recurrence of hepatitis C after liver transplantation. Surg Today 2003; 33:421-425.

21. Sugo H, Balderson GA, Crawford DHG, Fawcett J, Lynch SV, Strong RW, Futagawa S. Overseas liver transplantation for hepatitis C in Japanese patients: a comparison with patients from Australia/New Zealand. Transplantation Proceedings 2002;34:3323-3324

22. Whiting PW, Fletcher LM Dixon JK, Gochee P, Powell LW, Crawford DHG. Concordance of iron indices in homozygote and heterozygote sibling pairs in hemochromatosis families: Implications for family screening. J Hepatol 2002; 37:309-314.

23. Sugo H, Balderson GA, Crawford DH , Fawcett J, Lynch SV, Strong RW, Futagawa S: Overseas liver transplantation for hepatitis C in Japanese patients: a comparison with patients from Australia/New Zealand. Transplant Proc 2002, 34:3323-3324.

24. Wallace JD, Abbott-Johnson WJ, Crawford DHG, Barnard R, Potter JM, Cuneo RC. GH Treatment in Adults with Chronic Liver Disease: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study. J Clin Endocrinol & Metab 2002; 87(6):2751-2759.

25. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DH: Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology 2002, 122:281-289.

   Editorial: Britton RS and Bacon BR: Hereditary Hemochromatosis and Alcohol: A fibrogenic cocktail. Gastroenterology 2002: 122:563-564

26. McCullen MA, Crawford DHG, Hickman PE. Screening for haemochromatosis. Clinica Chimica Acta 2001;315:169-186.

27. Macdonald GA , Bridle KR, Ward PJ, Walker NI, Houglum K, George DK, Smith JL, Powell LW, Crawford DHG, Ramm GA. Lipid peroxidation in hepatic stenosis in humans is associated with hepatic fibrosis and occurs predominantly in acinar zone 3. J Gastro & Hepatol . 2001;6: 599-606.

28. Haber P, Nakamura M, Tsuchimoto K, Ishii H, Keogh GW, Apte MV, Moran CS, Stewart NL, Crawford DH, Priola RC, McCaughan GW, Ramm GA, Wilson JS, Nishino H, Kohno M, Aizawa, Tajima N, Maruyama K, Takahashi H, Matsushita S, Okuyama K, Yokoyama A, Nakamura Y, Shirakura K, Conigrave KM, Hu BF, Camargo CA Jr, Stampfer MJ, Willett WC, Rimm EB. Alcohol and the Pancreas. Alcohol Clin.Exp.Res . 2001; 5 Suppl ISBRA):244S-250S.

29. Lott WB, Takyar SS, Tuppen J, Crawford DH, Harrison M, Sloots TP, Gowans EJ. Vitamin B12 and hepatitis C: molecular biology and human pathology. Proc.Natl.Acad Sci USA . 2001;98(9):4916-21.

30. Bridle KR, Crawford DHG, Powell LW, Ramm GA . Role of myofibroblasts in tumour encapsulation of hepatocellular carcinoma in haemochromatosis. Liver. 2001; 2: 96-104 .

31. Jonsson JR, Hong C, Purdie DM, Hawley C, Isbel N, Butler M, Balderson GA, Clouston AD, Pandeya N, Stuart K, Edwards-Smith C, Crawford DH, Fawcett J, Powell EE. Role of cytokine gene polymorphisms in acute rejection and renal impairment after liver transplantation . Liver Transpl. 2001;7(3):255-63.

32. Lehnert ME, Clarke DD, Gibbons JG, Ward LC, Golding SM, Sheperd RW, Cornish BH, Crawford DH. Estimation of body water compartments in cirrhosis by m,ultiple-frequency bioelectrical-impedance analysis. Nutrition. 2001;1:31-4.

33. Stuart KA, Fletcher LM, Clouston AD, Lynch SV, Purdie DM, Kerlin P, Crawford DH. Increased hepatic iron and cirrhosis: no evidence for an adverse effect on patient outcome following liver transplantation. Hepatology . 2000;32(6):1200-7.

Editorial: Keefe EB . Liver transplantation in patients with hepatic iron overload: Favorable or unfavourable outcome? Hepatology 2000 32:1200-1207

34. Gilroy RK, Lynch SV, Strong RW, Kerlin P, Balderston GA , Stuary KA. Crawford DH. Confirmation of the role of the Mayo Risk Score as a predictor of resource utilization after orthotopic liver transplantation for primary biliary cirrhosis. Liver Transpl. 2000; 6:749-52.

35. Ramm GA, Carr SC, Bridle KR, Li L, Britton RS, Crawford DH, Vogler CA, Bacon BR, Tracey TF. Morphology of liver repair following cholestatic liver injury: resolution of ductal hyperplasia, matrix deposition and regression of myofibroblasts. Liver . 2000; 5:387-96.

36. Crawford DH, Fawcett J. Hepatocellular carcinoma in Australia : largely preventable? Med J Aust 2000 173(8):396-7.

37. Fanning PA, Jonsson JR, Clouston AD, Edwards-Smith C, Balderson GA, Macdonald GA, Crawford DHG, Kerlin P, Powell LW, Powell EE. Detection of male DNA in the liver of female patients with primary biliary cirrhosis. J Hepatol 2000;33:690-695.

38. McCullen MA, Crawford DH, Dimeski G, Tate J, Kickman PE. Why there is discordance in reported decision thresholds for transferrin saturation when screening for hereditary hemochromatosis . Hepatology 2000;32(6):1410-1.

39. Angus PW, McCaughan GW, Gane EJ, Crawford DHG, Harley H. Combination low-dose hepatitis B immune globulin and lamivudine therapy provides effective prophylaxis against posttransplantation hepatitis B. Liver Transpl . 2000 Jul;6(4):429-433.